Boss Cheat Sheet

Check before every Boss room β€” 30 seconds to know what matters

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πŸ”

Act 1 β€” The Exordium

The Guardian
HP: 240
Mediumβ–Ό
⚠️Never use multi-hit attacks in Defensive Mode β€” Thorns will shred your HP fast.
Hexaghost
HP: 250
Highβ–Ό
⚠️Do NOT drink HP potions before the fight β€” higher HP = harder first hit!
Slime Boss
HP: 140
Lowβ–Ό
⚠️Don't let Slimed cards pile up in your deck β€” they severely dilute your hand quality.

Act 2 β€” The City

The Collector
HP: 300
Highβ–Ό
⚠️Killing Torch Head buffs The Collector β€” think carefully before clearing minions.
Champ
HP: 440
Highβ–Ό
⚠️His Block resets every turn β€” low-output builds can't break through. Stack Poison or save a burst turn.
Bronze Automaton
HP: 300
Mediumβ–Ό
⚠️Kill Bronze Orbs first β€” ignoring them lets their sustained damage overwhelm you.

Act 3 β€” The Beyond

Aeonglass
HP: 512
Highβ–Ό
⚠️Never let Withers pile up in hand β€” each unplayed Wither deals 2 damage at end of turn. Multiple retained Withers kill faster than any attack.
Awakened One
HP: 300
Extremeβ–Ό
⚠️Save your potions for Phase 2! Revival puts you under immediate pressure with no time to set up.
Donu & Deca
HP: 300 / 300
Extremeβ–Ό
⚠️Kill Deca first! Letting it keep stacking shields on Donu makes the fight infinite.

Act 4 β€” The Heart

The Corrupt Heart
HP: 750
Extremeβ–Ό
⚠️Beat of Death is the deadliest mechanic β€” every card you play damages YOU. Keep your deck lean; never add junk cards.
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Boss Cheat Sheet β€” Slay the Spire 2 | STS2 Guide